Ampicillinsulbactam is a combination of the common penicillinderived antibiotic ampicillin and sulbactam, an inhibitor of bacterial betalactamase. A compound, c8h11no5s, that inhibits action of the enzyme betalactamase, thus counteracting bacterial resistance to betalactam antibiotics. Sulbactam sodium combination price of 25 brands trade. Sulbactam sodium, chemical structure, molecular formula. Unasyn ampicillin sodium, sulbactam sodium how supplied. This sulbactam cefoperazone combination is available as a dry powder for reconstitution in a 1. Packaging and storage preserve in tight containers. Comparative activities of the betalactamase inhibitors ytr.
Sulbactam is able to inhibit the most common forms of. The length of treatment depends on the type of infection you have. Your doctor will tell you how long to use ampicillin and sulbactam injection. Our specialization, your confidencewe keep committing to meet the. Unasyn ampicillin sodiumsulbactam sodium dose, indications. Sulbactam sodium manufacturerhigh qualitybest pricein stock. Ampicillin and sulbactam injection comes as a powder to be mixed with liquid and injected intravenously into a vein or intramuscularly into a muscle every 6 hours 4 times daily.
Sulbactam sodium is a weak antibiotic but its action a s an irreversible inhibitor of. Chemically, it is known as either sodium penicillinate sulfone or sodium 2s, 5r3,3dimethyl7oxo4thia1azabicyclo3. Dailymed ampicillin and sulbactam ampicillin sodium and. The antimicrobial effect of piperacillin can be enhanced by the two combined. Jan 03, 20 piperacillin sodium and sulbactam sodium for injection 2. It was patented in 1977 and approved for medical use in 1986. Unasyn ampicillin sodiumsulbactam sodium is supplied as a sterile offwhite dry powder in glass vials and piggyback bottles. Cefaperazone is a semi synthetic broad spectrum cephalosporin antibiotic. Addition of sulbactam increases resistance to betalactamases, enzymes produced by bacteria that may inactivate ampicillin. Unasyn dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. Dec 21, 2008 an isocratic liquid chromatographic method with uv detection at 220 nm is described for simultaneous determination of ceftriaxone sodium and sulbactam sodium in sulbactomax. Learn about drug interactions between ampicillinsulbactam iv and sodium bicarbonate iv and use the rxlist drug interaction checker to check drug combinations. Pdf simultaneous determination of ampicillin sodium and. Piperacillin sodium and sulbactam sodium for injection 2.
May cause allergy or asthma symptoms or breathing difficulties if inhaled. Dailymed ampicillin sodium and sulbactam sodium injection. Chromatographic separation of two drugs was achieved on a hypersil ods c18 column using a mobile phase consisting of a binary mixture of acetonitrile and tetrabutyl. Bhattacharya ss, bharti n, banerjee s 2014 process validation of ceftriaxone and sulbactam dry powder injection. Comparative activities of the betalactamase inhibitors ytr 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Material safety data sheet of sulbactam sodium abmole. Drugs az pill identifier supplements symptom checker diseases dictionary media. The ddds for the antiinfectives are as a main rule based on the use in infections of moderate severity. Sulbactam sodium is a semi synthetic penem antibiotic formed by the oxidation of penicillanic acid to its sulfone and was invented by barth at pfizer in 1978. Accidental release measures contain spill and collect, as appropriate. Ampicillinsulbactam is a combination of antibiotics made up of ampicillin, a betalactam and sulbactam, a betalactamase inhibitor introduced in the eighties. Sulbactam sodium contains not less than 886g and not more than 941g of sulbactam c 8 h 11 no 5 sper mg,calculated on the anhydrous basis. Sulbactam sodium european pharmacopoeia ep reference standard.
To reduce the development of drug resistant bacteria and maintain the effectiveness of. Sulbactam sodium is a derivative of the basic penicillin nucleus. Unasyn ampicillin sodiumsulbactam sodium powder for. Fixed combination of ampicillin sodium an aminopenicillin and sulbactam sodium a. This medication is given by injection into a vein, usually every 6 hours or as directed by your doctor. A01ab antiinfectives and antiseptics for local oral treatment a02bd combinations for eradication of helicobacter pylori. Get info of suppliers, manufacturers, exporters, traders of sulbactam sodium injection for buying in india. The sodium content per vial is 1150 mg 50 meq sodium. Overdosage of the drug would be expected to produce manifestations that are principally extensions of the adverse reactions reported with the drug. Ampicillin and sulbactam for injection pharmacy bulk package is a vial containing a sterile preparation of ampicillin sodium and sulbactam sodium for parenteral use that contains many single doses.
Sulbactam sodium definition of sulbactam sodium by the free. Sulbactam sodium synonyms, sulbactam sodium pronunciation, sulbactam sodium translation, english dictionary definition of sulbactam sodium. Capitals indicate lifethreatening, underlines indicate most frequent. Find here online price details of companies selling sulbactam sodium injection. Unasyn is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the betalactamase inhibitor sulbactam sodium for intravenous and intramuscular administration ampicillin sodium is derived from the penicillin nucleus, 6aminopenicillanic acid. Sulbactam sodium definition of sulbactam sodium by the. Addition of sulbactam increases resistance to betalactamases, enzymes. Sulbactam is a semisynthetic betalactamase inhibitor. An isocratic liquid chromatographic method with uv detection at 220 nm is described for simultaneous determination of ceftriaxone sodium and sulbactam sodium in sulbactomax. Pdf the binary mixture of ampicillin sodium and sulbactam sodium is officially analyzed by hplc but can not be simultaneously determined. Ampicillin sodium and sulbactam sodium monograph for.
Create pdf files without this message by purchasing novapdf printer. The first, developed in 1987 and marketed in the united states under the tradename unasyn, generic only outside the united states, is an intravenous antibiotic. Unasyn ampicillin sodiumsulbactam sodium antibiotics. Ytr 830, a new betalactamase inhibitor, was compared with clavulanic acid and sulbactam against aminopenicillinresistant clinical isolates.
Antiinfectives are also classified in the following groups. Chemically, sulbactam sodium is sodium penicillinate sulfone. Sulbactam definition of sulbactam by medical dictionary. May 07, 2018 unasyn, ampicillin sodium sulbactam sodium parenteral combination, is available as a white to offwhite dry powder for reconstitution. Generic drug sulbactam sodium combination available with manufacturer details. Unasyn ampicillin sodiumsulbactam sodium pharmacy bulk. Limited information is available on the acute toxicity of cefoperazone sodium and sulbactam sodium in humans. Amoxycillin sodium, sulbactam sodium, tetra butyl ammonium hydroxide. Sulbactam sodiumampicillin sodium pfizer pro login page.
Usp dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. Stable for 8 hours at room temperature or 48 hours refrigerated at a maximum concentration of 45 mgml ampicillin. Its chemical formula is c8h10nnao5s with a molecular weight of 255. May be harmful by inhalation, ingestion, or skin absorption. A novel high performance liquid chromatographic method for. Unasyn ampicillin sodiumsulbactam sodium powder for injection. Sulbactam sodium is also a derivative of 6aminopenicillanic acid. Asterisks are no longer used or included within the product and package code segments to indicate certain configurations of the ndc.
Piperacillin sodium and sulbactam sodium for injection2. Click on the desired brand to find out the drug price or cost of the drug. Chemically, it is monosodium 2s, 5r, 6r6r2amino2phenylacetamido3. The sulbactam sodium and cefoperazone sodium combination consists of a betalactamase inhibitor plus a betalactam. However, some antiinfectives are only used in severe infections and their ddds are assigned accordingly. For research use only, not for human or veterinary use. How to use ampicillin sulbactam vial with threaded port. Sulbactam sodium european pharmacopoeia ep reference. Aug 06, 2015 unasyn ampicillin sodiumsulbactam sodium powder for injection msds special notice. May 25, 2018 ampicillin and sulbactam for injection, usp dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. Sulbactam sodium salt cas 69388847 scbt santa cruz. The betalactam ring of sulbactam irreversibly binds to betalactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other betalactam antibiotics by the enzyme. At a concentration of 8 microgramsml, ytr 830 was as effective as clavulanate or sulbactam in reducing the aminopenicillin.